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Calm Cp Capsule Change

April 15, 2019

Calm CP – Same Active Formula, Higher Standardization

Calm CP by NeuroScience

Decreases cortisol levels and provides ingredients important for calm, sleep, and management of blood sugar*

  • This unique formula includes Banaba leaf that has been standardized to corosolic acid
  • Corosolic acid selectively inhibits 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), which is the enzyme that catalyzes the conversion of cortisone into cortisol (1,2)*

Higher standardization and smaller capsule size

  • The standardization of a botanical ensures the concentration of an active ingredient is at a specific desired amount
  • A higher concentrated form of Banaba leaf is now being used in the Calm CP formulation blend, replacing 2% with 18% corosolic acid
  • Using 18% corosolic acid results in a more concentrated proprietary blend, enabling Calm CP 60ct to be offered in a smaller, more convenient capsule size that improves the overall patient experience
  • An additional benefit of a smaller formulation blend is less excipients are required to produce the same active formula

Same active formula

  • The total active ingredients in the Calm CP formula as well as the amount of Calm CP delivered using 18% corosolic acid is equal to using 2% corosolic acid
  • The new lot of Calm CP was subject to independent third party post production testing to confirm ingredients meet label claims

Excipient transparency

  • Calm CP 60ct now contains rice flour as an excipient, an equivalent excipient to magnesium stearate

Aesthetic changes to Calm CP 60ct

  • The new 18% corosolic acid capsules are smaller and white in contrast to the larger brown 2% corosolic acid capsules
  • The capsule size is noticeably smaller than the 16ct and previous 60ct capsules due to the more concentrated proprietary blend
  • The formula will appear whiter than the previous capsules as less excipients are required
  • The image above illustrates the visible differences in size and color between the two capsules These changes are not affecting Calm CP 16ct at this time


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References:

  1. Patel H, et al. Arabian Journal of Chemistry. 2015.
  2. Rollinger J, et al. Bioorg Med Chem. 2010;18(4):1507-15.