April 15, 2019

Calm CP – Same Active Formula, Higher Standardization

Calm CP by NeuroScience

Decreases cortisol levels and provides ingredients important for calm, sleep, and management of blood sugar*

This unique formula includes Banaba leaf that has been standardized to corosolic acid
Corosolic acid selectively inhibits 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), which is the enzyme that catalyzes the conversion of cortisone into cortisol (1,2)*

Higher standardization and smaller capsule size

The standardization of a botanical ensures the concentration of an active ingredient is at a specific desired amount
A higher concentrated form of Banaba leaf is now being used in the Calm CP formulation blend, replacing 2% with 18% corosolic acid
Using 18% corosolic acid results in a more concentrated proprietary blend, enabling Calm CP to be offered in a smaller, more convenient capsule size that improves the overall patient experience
An additional benefit of a smaller formulation blend is less excipients are required to produce the same active formula

Same active formula

The total active ingredients in the Calm CP formula as well as the amount of Calm CP delivered using 18% corosolic acid is equal to using 2% corosolic acid

Excipient transparency

Calm CP now contains rice flour as an excipient, an equivalent excipient to magnesium stearate

Aesthetic changes to Calm CP 60ct

The new 18% corosolic acid capsules are smaller and white in contrast to the previous larger brown 2% corosolic acid capsules
The capsule size is noticeably smaller than the previous 60ct capsules due to the more concentrated proprietary blend
The formula will appear whiter than the previous capsules as less excipients are required
The image above illustrates the visible differences in size and color between the previous and current capsules

References: